Pulmonary toxicity of malaria prophylaxis.

Pulmonary toxicity of malaria prophylaxis.

Correspondence t Davidson. The increased use of malaria prophylaxis has led to more reports of drug induced toxicity. Hepatic, renal, skin, and bone marrow effects are well recognised. Five cases of pulmonary toxicity and systemic illness after the use of pyrimethamine-sulfadoxine (Fansidar) have been reported.'-' In two of these reports rapidly progressive respiratory failure developed and ope...

Prophylaxis of Malaria

Malaria prevention in travelers to endemic areas remains dependent principally on chemoprophylaxis. Although malaria chemoprophylaxis refers to all malaria species, a distinction should be drawn between falciparum malaria prophylaxis and the prophylaxis of the relapsing malaria species (vivax & ovale). While the emergence of drug resistant strains, as well as the costs and adverse reactions to ...

Malaria prophylaxis for travellers.

Quinine Prophylaxis in Malaria

In the effect of quinine on the malarial parasite we have perhaps the most remarkable example of the specific action of a drug in the whole range of medicine and one which has stood the test of two and a half centuries. Yet we have the apparent paradox of the frequently reported failure of the drug prophylactically against malaria. It is abundantly proved that when a primary infection of malari...

Prophylaxis of pulmonary embolism.

The three factors which catalyse thrombus formation and intravascular coagulation are changes in the rate of blood flow, changes in the vessel wall, and changes in the nature of the blood. These factors, which were enumerated over a hundred years ago by Rudolph Virchow,47 are still our main guide lines. The various causes of changes in blood flow are well known. The antithrombotic properties of...